Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicine

Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicine.

Acute lymphoblastic leukemia (ALL) is the commonest childhood tumor and remains a leading cause of cancer death in the young. In the last decade, microarray and sequencing analysis of large ALL cohorts has revolutionized our understanding of the genetic basis of this disease. These studies have identified new ALL subtypes, each characterized by constellations of structural and sequence alterati...

Precision medicine for all? Challenges and opportunities for a precision medicine approach to critical illness

All of medicine aspires to be precise, where a greater understanding of individual data will lead to personalized treatment and improved outcomes. Prompted by specific examples in oncology, the field of critical care may be tempted to envision that complex, acute syndromes could bend to a similar reductionist philosophy-where single mutations could identify and target our critically ill patient...

Detecting All Accepting Cycles

Detecting All High-Level Dataraces in an RTOS Kernel

A high-level race occurs when an execution interleaves instructions corresponding to user-annotated critical accesses to shared memory structures. Such races are good indicators of atomicity violations. We propose a technique for detecting all high-level dataraces in a system library like the kernel API of a real-time operating system (RTOS) that relies on flag-based scheduling and synchronizat...

High-speed All- Optical Time Division Multiplexed Node

In future high-speed self-routing photonic networks based on all-optical time division multiplexing (OTDM) it is highly desirable to carry out packet switching, clock recovery and demultplexing in the optical domain in order to avoid the bottleneck due to the optoelectronics conversion. In this paper we propose a self-routing OTDM node structure composed of an all-optical router and demultiplex...